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It promotes the macrophage transition from M1 (pro-inflammatory) to M2 (anti-inflammatory)

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UU.: Elsevier Academic Press

12885_2025_13546_MOESM2_ESM.tif (download TIF Supplementary Material 2: Supplementary Fig

Biochemical and Biophysical Research Communications , 482 (4), 625631

For instance, when peripheral tissues become inflamed, the related signals might be transmitted to the brain through these receptors on the neurons, and the brain could then respond to these signals via neural pathways, thus regulating the level of peripheral inflammation