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In our simplified overview, we are interested in the MAP3K members named apoptosis signal-regulating kinase 1 and 2 (referred to singly as ASK1/2), the MAP2K member named MKK4, and the MAPK member named c-Jun N-terminal kinase (JNK)

Molecular Basis of G6PD Deficiency In principle, genetically determined deficiency of G6PD, like that of any other protein, might be attributed either to quantitative changes, such as mutations that affect the amount of the enzyme but not its structure, or to qualitative changes, such as mutations that affect the structure of the enzyme and hence its stability or catalytic efficiency

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118 Winkel-ShirleyB

Mutations in the superoxide dismutase 1 (SOD1) gene are associated with familial forms of ALS [167]