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Moreover, PHGDH upregulation correlates with increased ROS generation, oxidative stress, and hypoxia-inducible factor-1 (HIF-1) activation, all of which promote metastasis in animal and cellular models (56, 57)

Superoxide dismutase is most powerful body antioxidant Superoxide dismutase - an antioxidant enzyme produced by every cell in the body that reduces potentially harmful oxygen free radicals produced during normal metabolic activity of a cell