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Astrocytes span around the vascular endothelium and pericytes via end-feet, and regulate BBB permeability (Figure 1)

Hypoxic stress may alter circulating extracellular vesicle (cEV) microRNA (miRNA) content, thereby influencing the liver microenvironment

Knockdown of myeloid cell hypoxia-inducible factor-1 Ameliorates the acute pathology in dss-induced colitis

Balogun O, Wang JY, Shaikh ES, Liu K, Stoyanova S, Memel ZN, et al

These findings show that TGR is likely to serve multiple functions in the parasite and is functionally distinct from the TrxR and GR orthologs of the human host

Figure 5 Proof of concept experiments that support the hypothesis of chronic glutamate toxicity in neurodegeneration As EAATs have been found to be down-regulated in many diseases of the nervous system (Sheldon and Robinson, 2007) and hypothetically increased L-glu and L-asp clearance should dampen the excitotoxic component of these diseases, many researchers have set out to identify compounds that induce EAAT2, which is the principal EAAT in the brain and most frequently found to be downregulated (Sheldon and Robinson, 2007