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Longer regimens remain viable for patients with additional resistance, intolerance to short-course drugs, severe disease, pregnancy, certain extrapulmonary TB cases, or other complex needs, with alternative agents recommended as needed (i.e., streptomycin, levofloxacin, clofazimine, and delamanid) (Vanino et al., 2023)

Under the effect of genetic change or the environment (e.g., heavy metal toxicity and altered gut microbiota), the activation of pathological apoptosis (elevation of caspases) impairs normal brain maturation and induces autistic phenotype

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