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SKU: 95448741675
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SKU: 95448741675 · From southroadsurgery.com.au

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Description

GPX4 and DHODH constitute the two primary defense weapons against lipid peroxidation in mitochondria

Cells were treated either with DMSO or various concentrations of RSL3 (0.53.0 M) for 48 h

Additional regulatory mechanisms include SRC-2mediated reductive carboxylation, compensatory glutamine addiction induced by PDHA1 loss, Guanine Monophosphate Synthetase(GMPS) driven purine biosynthesis, reciprocal regulation between GLS and CAD, epigenetic modulation via MeCP2/DNMT, and C5a complement signaling that promotes glutamine consumption in castration-resistant prostate cancer (4143)