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MS takes the methyl group from 5-methyltetrahydrofolate (5-MTHF) and transfers it to Hcy in a reaction that yields methionine and tetrahydrofolate (THF), which reacts with serine to produce 5,10-methylene-THF (5,10-CH 2 THF) that is again converted into 5-MTHF by the enzyme MTHFR