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Clinical Studies 14.1 Non-Squamous NSCLC Initial Treatment in Combination with Pembrolizumab and Platinum The efficacy of pemetrexed in combination with pembrolizumab and platinum chemotherapy was investigated in Study KEYNOTE-189 (NCT02578680), a randomized, multicenter, double-blind, active-controlled trial conducted in patients with metastatic non-squamous NSCLC, regardless of PD-L1 tumor expression status, who had not previously received systemic therapy for metastatic disease and in whom there were no EGFR or ALK genomic tumor aberrations

Treatment is often initiated at a high dose, followed by a maintenance dose given less frequently, as determined by the patient's B12 levels and clinical response

3 times per week for 2 weeks) followed by a maintenance phase (weekly or biweekly injections)

Despite the different dosages, it is striking that the amounts of B12 absorbed in the end are very similar to one another

Hopeful second month will have good results also