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Apart from the effects of these medications on vitamin B12 status, drugs that inhibit acid secretion have been observed to have negative impacts on the status of certain other micronutrients and the microbiome

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The MHRA product information for hydroxocobalamin preparations lists several recognised side effects that patients should be aware of before commencing treatment

In contrast, the Trinity Ulster Department of Agriculture Ageing Cohort Study (TUDA) study did observe a positive association of folate with depression risk using erythrocyte folate (instead of plasma folate) as a marker of folate status, though the study did not control for important covariates such as vitamin D status (Reference Moore, Hughes and Hoey17)