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Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes

In addition, a synthetic lethal relationship exists between the oncogenic activity of IDH2 and the serine synthesis pathway in both TNBC and HER2-positive breast cancer, rendering cells with high IDH2 expression particularly sensitive to PHGDH or PSAT1 inhibition (71)

L-Serine itself can act as a feedback inhibitor of PHGDH in certain organisms, ensuring that excess serine slows its own production [21]

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Additionally, they can be utilized in targeted therapy, gene therapy, and in combination with current cancer treatments to synergistically enhance their effectiveness