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Weeks 25-48+: Continued progress beyond what dual agonists can achieve

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In support of this, a recent study has shown that Nrf2, the master regulator of antioxidant response plays a role in mitohormesis (induced by a small degree of mitochondrial uncoupling) in skeletal muscle of transgenic mice deficient in oxidative phosphorylation capacity (25)

It is not FDA-approved, is not a weight-loss medication, and any use should be discussed with a qualified prescriber

The cumulative mortality rates per 1000 person-years for all-cause was 37.60, 61.46 and 102.62 for patients with MMA levels in T1, T2 and T3, respectively (Fig