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Inhibition of the mPTP and lipid peroxidation is additively protective against I/R injury

J.Miranda MassariJ

The luciferin formed is detected in a coupled reaction using Ultra-Glo Recombinant Luciferase that generates a glow-type luminescence that is proportional to the amount of glutathione present in cells

While TAU's affinity for isolated lysosomes may not be perfectly tailored for CMA substrate interaction, truncated TAU mutants do not completely translocate into the lysosomal lumen for degradation, despite the existence of two CMA targeting motifs in TAU C-terminal region (179)

FOXO1, a pro-apoptotic transcription factor in cartilage, was investigated and it was found that silencing of FOXO1 in chondrocytes resulted in a significant reduction in the mRNA levels of pro-apoptotic genes caspase-3, caspase-8, caspase-9 and TRAIL