J Diabetes Complications (2013) 27(2):1237
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J Biol Chem 118:531538
Basics and Recent Advances in Peptide and Protein Drug Delivery
tissue-protective effects persist longer Synonyms : Cibinetide, pHBSP, ARA290, Helix-B Surface Peptide Type : Synthetic non-erythropoietic peptide (EPO helix-B analog) Research Focus : Neuropathic Pain, Anti-inflammatory & Tissue Protection Scientific References ARA 290, a specific agonist of erythropoietin/CD131 heteroreceptor, improves circulating endothelial progenitors angiogenic potential and homing ability Human RCT | In vitro ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss and increases corneal nerve fiber density Human RCT Effect of the innate immune modulator ARA 290 on inflammation-related biomarkers in patients with sarcoidosis: A phase 2a study Human RCT A nonhematopoietic erythropoietin analogue, ARA 290, inhibits macrophage activation and prevents damage to transplanted islets Animal | In vitro ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury Animal Cibinetide improves quality of life in patients with sarcoidosis-associated small fiber neuropathy Observational | Human RCT The non-hematopoietic erythropoietin analog ARA 290 attenuates neuropathic pain and acute inflammation Animal | In vitro Cibinetide reduces hyperalgesia and improves metabolic control in type 2 diabetes patients with neuropathy Human RCT Included In The Box Every product arrives in a premium, custom-designed PEPTIDE.Power box , engineered for convenience, hygiene, and safe storage in your refrigerator
