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Disclosures: Miriam Longo: Nothing to Disclose, Erika Paolini: Nothing to Disclose, Marica Meroni: Nothing to Disclose, Anna Alisi: Nothing to Disclose, Giorgio Soardo: Nothing to Disclose, Anna Ludovica Fracanzani: Nothing to Disclose, Paola Dongiovanni: Nothing to Disclose 841 PLIN2 IS A SPECIFIC MARKER FOR MASH AND IS NOT A MARKER FOR CARDIOVASCULAR DISEASE OR DIABETES Giulia Angelini Sara Russo 1 Aldo TRYLESINSKI 2 Federico Biscetti 1 Andrea Flex 1 Vlad Ratziu 3 Mazen Noureddin 4 Jrn Schattenberg 5 Amalia Gastaldelli 6 Luca Miele 1 Geltrude Mingrone 1 , 1 Universit cattolica del sacro cuore, 2 Metadeq Diagnostic, 3 Service D' Hepatogastroenterologie (FR), 4 Houston Methodist Hospital, 5 Department of Medicine II, 6 CNR Background: Metabolic dysfunction-associated steatohepatitis (MASH) represents the leading cause of liver disease worldwide