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J Biol Chem (1990) 265(15):84708

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However, to date, the methods used to increase GPx expression are mainly the artificial over-expression of GPxs through transfections or infections

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Well-designed randomized clinical studies are needed to systematically evaluate the evidence for the use of these hepatoprotective agents as treatment options for APAP-induced liver injury, to determine the timing of initiation of the therapy, and to further define the optimal treatment regimen