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SCX is often utilized in qualitative proteomics experiments to increase proteome coverage Citation[235,236]

Since FAD is reported to be more easily dislodged from the structure of the MTHFR 677TT coded enzyme in its thermo-labile, low-activity form (105), one evolutionary benefit of this homozygous polymorphism may be its provision of dislodged un-utilized FAD for sustaining MAO enzyme activity and keeping vitamin B6 and D activated