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have observed that HIF is highly active under hypoxic conditions and promotes the transcription of the target gene ITGA6 , which, in conjunction with other integrins, is enriched in breast stem cells and promotes the acquisition of MDR phenotypes in breast cancer 48

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B 12 deficiency can cause preventable permanent injury and should be considered with new onset neurological conditions and symptoms suggestive of B 12 deficiency (See Low B 12 symptoms section below)