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Modern lifestyles, stress, poor diet, limited sun exposure, and environmental factors can all contribute to nutrient deficiencies

This is then regenerated into BH4 with the help of 5-MTHF from the folate cycle

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In this study, people with type 2 diabetes and both peripheral and autonomic diabetic neuropathy who took 1,000mcg of oral B12 for one year had significant improvements in all neurophysiological parameters, sudomotor function, pain score, and quality of life