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To establish AAV9-mediated argininosuccinate lyase (Asl) knockdown, 3-month-old male C57BL/6 J mice received a single tail-vein injection of AAV9-shAsl (1 10 viral genomes [vg]) to achieve systemic Asl knockdown

Proc Natl Acad Sci 88:46564660 Sechi G, Deledda MG, Bua G, Satta WM, Deiana GA, Pes GM, Rosati G (1996) Reduced intravenous glutathione in the treatment of early Parkinsons disease

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COMT) are implicated in the initiation of breast cancer through the generation of genotoxic metabolites (i.e., estrogen quinones) and reactive oxygen species (ROS), and the depletion of vital antioxidants and metabolic cofactors