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The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis

In contrast, 468 susp cells completely failed to attach and hence any focal contacts were absent (data not shown)

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38 Downregulated signaling pathways AMPK signaling pathway AMPK is a pivotal serine/threonine protein kinase that plays an extensive role in the regulation of cellular energy metabolism 39

Secondly, long term effects of TCM are difficult to evaluate, because the clinical sample size are limited and the long term follow-up studies are deficient