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Methods 38 patients were included in a cross-sectional survey

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Semaglutide is often preferred for patients with milder weight-loss goals or histories of severe GI side effects, because tirzepatide tends to produce stronger nausea during titration

Exogenous administration of FGF21 in DIO in mice show virtually no beneficial effects on glucose tolerance and lipid metabolism, suggesting that the obesity state is FGF21-resistant (240)

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