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10.1016/j.biopha.2021.111872 79 RitchieR

Consistent with murine ILC2s, melatonin increased human ILC2 expression of GCLC, the rate-limiting enzyme in glutathione synthesis, as well as NRF2 ( Figures 8B, C )

It is a co-factor for methionine synthase, an enzyme involved in the methylation cycle, which is crucial for the metabolism of amino acids and the production of neurotransmitters

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Peptide hormones work by binding to specific receptors on the surface of target cells, initiating a cascade of intracellular events that result in the desired biological effect

Adjusted for age, sex, comorbidity score, diabetes, liver disease, active smoker, BMI, baseline eGFR and recruitment period