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2008], and has been reported in an ever growing number of carcinomas, including thyroid [Di Renzo et al

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In silico and in vitro investigations on the protein-protein interactions of glutathione S-transferases with mitogen-activated protein kinase 8 and apoptosis signal-regulating kinase 1

Indeed, antioxidants are believed to be overwhelmed by free radicals when their production surpasses the body's ability to counteract them with natural antioxidant defenses [137]

For more than 80 years since the discovery of VC, its physiological activities and biological functions have been continuously developed ( Nowadays, the industrial production of VC mainly relies on the classic two-step fermentation method (CTFR) to convert D-sorbitol to 2-keto-L-gulonic acid (2-KLG, the precursor for VC) ( In addition, researchers have been working on the production of VC in one-step fermentation over the years

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