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The Baar et al

Even successful CAR T-cell therapy may fail to reverse established organ damage in autoimmune diseases, as demonstrated by SLE-related glomerulosclerosis, pulmonary fibrosis in systemic sclerosis, exocrine gland fibrosis in Sjgrens syndrome, and demyelinating lesions in multiple sclerosis

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Determining if the EHBDs are involved is important as currently most research focuses on the liver parenchyma and the intrahepatic biliary tree without looking at the EHBD, which are known to be affected in the majority of PSC patients 6