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10.1016/j.phrs.2022.106361 172 SusaK.KobayashiK.GalichonP.MatsumotoT.TamuraA.HiratsukaK.et al (2023)

The chemical antidote to acetaminophen poisoning that McNeil helped to develop has a high success rate if administered within eight hours of an overdose

One possible explanation for the marginal drop in cytotoxicity is due to the presence of PEI which functions as a proton sponge after cell uptake and eventually destroys the endosome/lysosome 16

Conclusions It is exciting to observe that biotechnology applications of protein splicing have begun to move from proof-of-concept experiments to productive applications in which the intein is the tool rather than the object of study itself

However, neurological symptoms typically lag behind haematological improvement