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The major importance of paracrine/autocrine IGF-I was demonstrated by liver specific Igf1 ko mice ( Ligf1 ko) with largely unaffected longitudinal growth (33)

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The study involved 203 obese patients who were assigned to receive tesofensine at different doses or a placebo, in addition to an energy-restricted diet, for 24 weeks

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For comparison, liraglutide 3.0 mg (the active comparator) produced 9.0% reduction