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Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes

Modanloo M, Shokrzadeh M

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6 Challenges and future perspectives Despite the compelling preclinical evidence and promising early clinical results, the full translation of SFNs potential into reliable clinical applications faces several significant challenges