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( B ) Western blot of WT, sgNPC1 polyclonal, or sgNPC1 clonal K562 cell lines

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or C(R 7 , R 7a )C(R 8 , R 8a )

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Acetoacetate, -keto acids, flavour esters, methyl ketones and lactones flavour ingredients are synthesized due to the free fatty acids by the initiating of simple chemical reactions [198, 199]