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Chi M, Esteves A, Tuinier R, Friedrich H

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Figure 1 4.2.1 Butyrate: a paradigm of concentration-dependent epigenetic immunomodulation via the concentration-cell-therapy axis Butyrate, a key gut microbial SCFA, embodies a unified concentration-cell type-therapy context framework that resolves its dual immunomodulatory effects, linking epigenetic regulation to therapeutic outcomes

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In OA cartilage, chondrocytes display alterations in mitochondrial activity, such as decreased ATP generation and increased oxidative stress, which can contribute to cartilage deterioration