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849 In animal models of intestinal I/R, ferroptosis occurs primarily during the reperfusion phase due to the inactivation of the GSH/GPX4 pathway

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The second reason is based on several previous studies that assure the negative impact of these dosage levels on various organs of rats 33,34,35

The link of SLC7A11 to GPX4 is further determined [34], SLC7A11 mediates cystine uptake, subsequently, activates Rag-mTORC14EBP pathway-induced GPX4 protein synthesis

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