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Compared to the group that was not given corticosterone, the level of the mtDNA oxidative damage marker (8-oxodG) reached considerably higher values ( Another animal study evaluated the effects of chronic stress induced by immobilizing an animal for 21 days on the activity of oxidative stress-related indicators

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As a result, pyridoxine deficiency can lead to relevant neuropsychiatric manifestations, such as reduced neurotransmitter synthesis, depression, epilepsy, premature aging of neurons, paresthesias, cerebrovascular diseases, cognitive impairment and carpal tunnel syndrome (58) In contrast, pyridoxine may have therapeutic potential for treating depression or aggressive behavior, since pyridoxine plays a crucial role in the tryptophan-serotonin pathway (61, 62)

**Common side effects** of Botox include neck pain, muscle weakness, and slight bruising at the injection sites