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Causes of vitamin B12 deficiency Pernicious anaemia Pernicious anaemia is the most common cause of vitamin B12 deficiency in the UK

NNMT knockdown in a more aggressive squamous cell line contributed to the downregulation of epithelialmesenchymal transition (EMT)-related genes, including MMP9 , osteopontin ( OPN ), and versican core protein ( VCAN ), which are involved in focal adhesion and extracellular matrix (ECM)receptor interaction ( Cancer-associated fibroblasts (CAFs) are a fibroblast subpopulation that secrete pro-oncogenic cytokines and ECM-modifying factors promoting and supporting malignant cell growth and invasion (75)

Most people can get enough vitamin B12 in foods they eat already, such as fish, meat poultry, eggs, dairy products, and foods that are fortified with B12 (like some breakfast cereals)

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What is more, the vitamin B12 forms we have discussed above do not work alone in the body, but are part of a large complex of B vitamins and operate in combination with a number of other vitamins and minerals