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Though this is speculative rather than evidence-based

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doi:10.3390/jcm5110093

CR, Josephs KA (2012) Primary lateral sclerosis as progressive supranuclear palsy: Diagnosis by diffusion tensor imaging

Some people may have poor B12 absorption due to genetics and therefore need an individual B12 intake plan to maintain healthy levels (Temova Rakua et al., 2022)

Blood-thinning medication, certain blood disorders, active infection, uncontrolled diabetes and inflammatory joint disease may affect whether PRP is appropriate or how it should be planned