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Secondly, it may activate short-chain fatty acid receptors (SCFA receptors) and inhibit histone deacetylase (HDAC) activity, thereby lifting transcriptional repression on key iron absorption genes (such as Dcytb and Ferroportin) and consequently upregulating intestinal iron uptake

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Moreover, SLC7A5 inhibitors could also be used for the treatment of patients with NSCLC without EGFR mutations (93)

J Drug Target (2017) 25(7):62636