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The persistent accumulation of abnormal proteins in the brain lead to death of brain cells over time, which causes decline in cognitive function

This is vastly more dilute than topical formulations, but isolated cells in culture have direct peptide access without any barrier to penetration

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This work identifies peroxisomal fatty acid oxidation as a critical metabolic pathway in DTP cells, as a consequence of the metabolic switch towards oxidative phosphorylation that has been described in DTP cells from multiple tumour types

(2010) J