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In glaucomatous lamina cribrosa cells, increased levels of unmethylated DNA in the TGF1 promoter were observed, along with increased expression of TGF 1, TGF2 , COL1A1 , and -SMA (McDonnell et al., 2016), ultimately promoting fibrosis (Figure 5E)

They evaluated mice with a diet rich in fats and sucrose and discovered over-expression of WNT4 in beta cells, which resulted in enhanced glucose-induced insulin production and reduced beta cell proliferation (159)

doi: 10.3389/fmicb.2011.00232 387 SimonenM.PalvaI

Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants