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In parallel, HFMCDD-fed mice developed moderate to advanced peri-sinusoidal/pericellular fibrosis (F2-3 to F4) with moderate to severe steatosis (grade 2-3) and hepatocyte ballooning (grade 1-2), reflecting human MASLD pathology

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Evening administration before bed aligns with natural growth hormone rhythms and appears to produce optimal results

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