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Zhang R, Xue B, Tao Y, Zhao H, Zhang Z, Wang X, Zhou X, Jiang B, Yang Z, Yan X, Fan K

These changes only to a small extent include the genes controlled by Nrf2

In parallel, targeted preclinical studies are needed to clarify how glutamine affects key molecular pathways underlying its observed effects

The implanted mice were still observed after the surgical removal of primary xenografts to evaluate whether the xenografts preserved the recurrence that characterizes the corresponding patient glioma

Important factors for the loading phase include: Severity of initial deficiency Presence of neurological symptoms Patients overall health status Response to initial doses as assessed through follow-up laboratory tests By following this guideline, doctors can quickly restore vitamin B12 levels

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