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Our group has recently shown that changes in maternal dietary DHA levels may impact differently on the ECS and molecular markers highlighted by increased synaptophysin levels in the neonate brain, CB1/2 receptor levels in dams and neonates brain, glial fibrillary acidic protein (GFAP) levels, and protein kinase A (PKA) phosphorylation in the cortex and ERK phosphorylation in the hippocampus of the progeny ( In vitro studies with long chain polyunsaturated fatty acids (LC-PUFAs) DHA or EPA were also able to modulate the ECS

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This indicates that epidermal lipid synthesis is altered postmenopause and is susceptible to regulation by HRT