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Description

SQSTM1 is known as an ubiquitin-binding protein and promotes the aggregation of cullin3-modified caspase-8 within p62-dependent foci, leading to cell apoptosis 50

Mulla, M.H

Predictors of severe Crohns disease

Citral has a negative chronotropic effect, likely due to enhanced PNS activity (598)

Incretin-based pharmacotherapy now offers a medical alternative, resulting in a 15 to 20% body weight loss close to that achieved with bariatric surgery and providing considerable cardiovascular benefit

Mechanisms of resistance to, and toxicities resulting from, IGF-1R-targeted drugs are well-catalogued, and there is general appreciation of the fact that a lack of biomarker-based patient stratification was a limitation of previous clinical trials