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Autophagic deficits in PD are also found in immune cells, which is particularly relevant because microglia are the predominant cell type responsible for clearing aggregated -synuclein in the CNS [142]

Rao AD, Sugar EA, Chang DT, Goodman KA, Hacker-Prietz A, Rosati LM, Columbo L, O'Reilly E, Fisher GA, Zheng L, Pai JS, Griffith ME, Laheru DA, Iacobuzio-Donahue CA, Wolfgang CL, Koong AC , Herman JM

EClinicalMedicine 40 , 101125 (2021)

But, lower Mn excretion did not decrease the serum concentration of Mn in LZG

The relatively low radical reactivity of fluorescein may lead to underestimation of potent antioxidants with rapid reaction kinetics

Ethical approval Compliance with ethical standards of research involving animals, animal experiments were approved by the ethical committee of Tehran University of Medical Sciences and were performed according to the universitys guidelines