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The authors noted that well-designed, adequately powered clinical trials were lacking, and that definitive efficacy claims could not be supported by the existing literature at the time of publication

183 Moreover, aspirin has been shown to counteract gemcitabine resistance by inducing G1 phase cell cycle arrest and enhancing the pro-apoptotic effects of gemcitabine in PANC-1 cells, primarily through the inhibition of GSK-3, which suppresses downstream targets such as cyclin D1 and Bcl-2

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Indeed, habits, such as alcohol abuse, increased consumption of saturated fat acids, or micronutrient-poor diets, contribute to the development of endotoxemia and chronic low-grade inflammation

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55 The Leis result further clarified why BCAAs metabolism of PDAC is lower than that of surrounding normal tissues and then turns to other ways to obtain nitrogen (Fig