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576 Tetrahydroxy stilbene glycoside (TSG) enhances the activation of Keap1/Nrf2/ARE and GSH/GPX4 signaling pathways, reduces ferroptosis by regulating the levels of ferroptosis-related proteins and enzymes, and thus inhibits the production and deposition of A in the brain of APP/PS1 mice, 577 suggesting that TSG may be a promising therapeutic agent for AD by targeting ferroptosis

1, Koschmieder et al

Abstract Genetic diversity in the apolipoprotein E (ApoE) gene has been identified as the major susceptibility genetic risk factor for sporadic Alzheimers disease (SAD)

For instance, animal models for SZ that show both high oxidative stress levels and PFC hypomyelination (such as the APO-SUS rats, and the rodent prenatal infection and hypoxia models) may be treated with antioxidants from a young age onwards to assess whether lowering oxidative stress can (partially) rescue myelination deficits in the PFC, together with PFC-dependent cognitive functioning, and evaluate the width of the therapeutic window

The yellow players

Methyleringsbalans modelstudies rond 1-methylnicotinamide (1-MNA) en het S-adenosylmethionine (SAM)-methyldonorsysteem