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The methodology was as follows: Peer-reviewed clinical literature indexed in PubMed and PubMed Central was searched with terms including: microneedling , micro-infusion , percutaneous collagen induction therapy , transdermal drug delivery , AquaGold , plus each named active ingredient (GHK-Cu, Argireline, niacinamide, Centella asiatica, hyaluronic acid molecular weight, recombinant epidermal growth factor)

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doi: 10.1056/NEJMra1004965 65 GiacomelliRGorlaRTrottaFTirriRGrassiWBazzichiLet al

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Deficiency leads to nerve damage (neuropathy), which presents as numbness, tingling, or weakness

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