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125 A study showed HDAC1 upregulation in nasal epithelial cells from AR patients, 126 and IL-4 increased HDAC1 expression, leading to nasal epithelial barrier dysfunction

Therefore, regulating gene transcription is one of the primary functions of non-histone acetylation

SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity

Cancers Cancer cells are susceptible to perturbation of thiol metabolism, where excessive iron release and subsequent lipid peroxidation contribute to carcinogenesis [224]