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Statistical significance between the experimental groups was determined by unpaired Students t-test, one-way ANOVA followed by Dunnett post hoc tests or two-way ANOVA followed by Bonferroni post hoc tests

doi: 10.1016/j.molmet.2021.101414 220

During model training, min-max normalization was applied to further enhance convergence speed and stability

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isolated means that the material is removed from its original environment (e.g., the natural environment if it is naturally occurring)

So, you need to consider the possible side effects before diving into DSIP