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Comment: Commenters indicated that the proposed data collection on Worksheet S-12 would be administratively burdensome and that it was often unclear how the hospital should perform the required calculations

The STI + CoQ10 and LTI + CoQ10 groups showed nearly no sciatic nerve healing

Storage Requirements: Resilient at room temperature during shipping

Symptoms include: Muscle cramps Irregular heartbeat Weakness or numbness 2

Most symptomatic children with biotinase deficiency exhibit serum biotinase activity at 10% of normal levels or undetectable, and biotin levels in the brain and CSF are typically even lower [72]

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