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Gross examination of the tumour revealed a 2.8 cm by 1.7 cm by 1.6 cm specimen that was bilobular in outline and included some bone and pigmented soft tissue

There is an ongoing phase 2/3 randomised, double-blind, placebo-controlled trial (NCT06126315) of the biological and clinical effects of acetyl-l-carnitine planning to recruit ~250 patients [88]

Cortisol levels are still elevated above evening baseline, preserving partial circadian receptor advantage while shifting nausea into late afternoon rather than sleep onset