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Data were presented as mean SD (6 mice in each group)

Test small batches for unusually sensitive lab compounds

Radioactive iodine therapy destroys overactive tissue within 3-6 months but often leads to permanent hypothyroidism requiring lifelong hormone replacement afterward

Clinically available TRK tyrosine-kinase inhibitors (TRKis) provide the most immediate avenue but act only on kinase-active receptor isoforms

10.1080/14789450.2020.1704260 178 ShinS.YuJ.TaeH.ZhaoY.JiangD.QiaoY.et al (2024)

CaiWWuSMingXLiZPanDYangXet alIL6 derived from macrophages under intermittent hypoxia exacerbates NAFLD by promoting ferroptosis via MARCH3-Led ubiquitylation of GPX4