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Even in the most recent years, such people underwent simple lab testing to exclude significant diseases, with serum B12 levels of just within the reference ranges often labelled as normal

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Intended exclusively for in vitro and in vivo scientific research by qualified professionals

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Statistical analysis A sample size of 300 participants provided an effective power of at least 96% for the two co-primary endpoints, and at least 43% for all confirmatory secondary endpoints, which were tested in a predefined hierarchical order (Supplementary Table 4)